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Dr. Majlinda Lako PhD

Home / Society Members / Dr. Majlinda Lako PhD

Dr. Majlinda Lako PhD

Dr. Majlinda Lako PhD

Researcher unique identifier: ORCID ID: 0000-0003-1327-8573
majlinda.lako@tesct.org

EDUCATION

  • 1998 PhD in Human Genetics, Newcastle University, UK
  • 1993 Master in Life Sciences, University of Manchester, UK

CURRENT POSITION(S)

  • 2009 – Prof. of Stem Cell Sciences, Institute of Genetic Medicine, Newcastle University, UK

PREVIOUS POSITIONS

  • 2009 – 2010 Sabbatical Fellow, Centro de Investigacion Principe Felipe, Valencia, Spain
  • 2008 – 2009 Reader in Stem Cell Sciences, Institute of Human Genetics, Newcastle University, UK
  • 2004 – 2008 Senior Lecturer, Institute of Human Genetics, Newcastle University, UK
  • 2003 – 2004 Lecturer, Institute of Human Genetics, Newcastle University, UK
  • 1998 – 2003 Senior Research Associate, Department of Biological Sciences, University of Durham, UK
  • 1994 – 1998 Research Associate, Department of Human Genetics, Newcastle University, UK

FELLOWSHIPS AND AWARDS

  • 2014 – 2018 HO2020 ERC Consolidator Fellowship, Institute of Genetic Medicine, Newcastle University, UK
  • 2009 – 2010 Sabbatical Fellowship Award received from Conselleria de Sanidad (Generalitat Valenciana) and the Instituto de Salud Carlos III (Ministry of Science and Innovation)
  • 1992 – 1993 Scholarship, Soros Foundation, University of Manchester, UK

SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

  • 2003 – 36 Postdocs (7 ongoing); 16 completed (2 ongoing) PhDs; 14 completed MSc
  • considerable
  • considerable

ORGANISATION OF SCIENTIFIC MEETINGS

  • 2018 Organiser and Co-chair of the Cornea and Ocular Session, ISER 2018, Northern Ireland
  • 2014 Organiser and Co-chair of Pluripotent Stem Cell Differentiation Session, BIRAX, Israel
  • 2011 Abstract Reviewer, ASH, USA
  • 2007 Organiser and Scientific Director of UK-USA Stem Cell Workshop, UK

INSTITUTIONAL RESPONSIBILITIES

  • 2018 – Deputy Director, Institute of Genetic Medicine, Newcastle University, UK
  • 2016 – Member of the Impact Committee, Faculty of Medical Sciences, Newcastle University, UK
  • 2014 – Member of the Fellowship Mentoring Committee, Faculty of Medical Sciences, Newcastle University, UK

PRINCIPAL ACTIVE GRANTS

  • 2018- 2020 MRC UK: Understanding the molecular and cellular complexity of human cornea through single cell analyses; £452,987: PI
  • 2018-2020 MRC UK: scEye-Map: Development trajectories of progenitor cell populations in the human eye at single cell resolution; £456,000: Co-I
  • 2018-2020 Macular Society UK: Exploiting the role of exosomes to treat age related macular degeneration and provide biomarkers for early diagnosis of the disease; £170,000: PI
  • 2018-2021 Fight for Sight UK: Assessing the feasibility of induced pluripotent stem cells to provide a disease model for Retinoblastoma; £170,000: PI
  • 2018-2020 RP Fighting Blindness UK: Investigating the role of alternative splicing in autosomal dominant retinitis pigmentosa using a PRPF31 patient specific induced pluripotent stem cell disease model; 210,000: PI
  • 2018-2021 MRC: An iPSC based screen for candidate pain modulating compounds: £617,062: Co-I
  • 2018-2019 Science and Technology Facilities Council: Morphological and topological image analysis for clinical diagnostics and monitoring of cornea damage; £120,000; Co-I
  • 2018-2021 H2020-MSCA-ITN-2018: European Training Network to Diagnose, Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder; £250,000; Co-I
  • 2018-2021 MRC DiMeN DTP PhD Studentship: A multidisciplinary study to uncover new regulators of retinogenesis in health and disease; £130,000; PI
  • 2017-2020 Macular Society UK: Understanding the role of autophagy in the pathogenesis of AMD using a patient specific iPSC model: £169,885; PI
  • 2017-2020 NCR3R CrackiT: 3D hiPSC derived laminated retina model: £ 1,100,000, Lead Academic PI
  • 2017-2020 ERASMUS + KA2- Capacity Building in Higher Education 890,000 euros, Co-I

SELECTED RELEVANT PUBLICATIONS (152 in total (total citations 10049, h index 48)

  • Dorgau B, Felemban M, Hilgen G, Kiening M, Zerti d, Hunt NC, Doherty N, Whitfield P, Hallam D, White K, Ding Y, Krasnogor N, Al-Aama J, Asfour HZ, Sernagor E and Lako M. Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids. Biomaterials 2019 (in press).
  • Collin J, Queen R, Zerti D, Dorgau B, Hussain R, Coxhead J, Cockell S and Lako M. Deconstructing Retinal Organoids: Single cell RNA-Seq reveals the cellular components of human pluripotent stem cell-derived retina. Stem Cells. 2018 Dec 12. doi: 10.1002/stem.2963.
  • Mellough CB, Bauer R, Collin J, Dorgau B, Zerti D, Dolan D, Jones CM, Izuogu OG, Yu M, Hallam D, Steyn JS, White K, Steel DH, Santibanez-Koref M, Elliott DJ, Jackson MS, Lindsay S, Grellscheid S and Lako M. An integrated transcriptional analysis of the developing human retina. Development 2018 (in press).
  • Collin J, Zerti D, Queen R, Santo-Ferreira T, Coxhead J, Hussain R, Steel D, Mellough C, Ader M, Sernagor E, Armstrong L and Lako M. CRX expression in pluripotent stem cell derived photoreceptors marks a transplantable subpopulation of early cones. Stem Cells 2018 (in press).
  • Buskin A, Zhu, L, Chichagova V, Basu B, Mozaffari-Jovin S et al, Luehrmann R, Grellscheid SN, Johnson CA and Lako M. Splicing factor PRPF31 retinitis pigmentosa (RP11) is caused by disrupted alternative splicing programmes for genes implicated in pre-mRNA splicing, cellular adhesion and ciliogenesis. Nature Communications 2018;9(1):4234.
  • Jeong M, O’Reilly M, Kirkwood NK, Al-Aama J, Lako M, Kros CJ, Armstrong L. Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells. Cell Death Dis. 2018; 9(9):922.
  • Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, Hewitt P, Schmitt M, Uteng M, Kustermann S, Steel D, Nicholds M, Thomas R, Treumann A, Porter A, Sernagor E, Armstrong L, Lako M. Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency. Stem Cells. 2018 Oct;36(10):1535-1551.
  • Dorgau B, Felemban M, Sharpe A, Bauer R, Hallam D, Steel DH, Lindsay S, Mellough C, Lako M. Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation. Cell Death Dis. 2018 May 23;9(6):615.
  • Felemban M, Dorgau B, Hunt NC, Hallam D, Zerti D, Bauer R, Ding Y, Collin J, Steel D, Krasnogor N, Al-Aama J, Lindsay S, Mellough C, Lako M. Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix. Acta Biomater. 2018 Jul 1; 74: 207-221.

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